Copley Scientific
System for Improved In Vitro-In Vivo Correlations (IVIVCs) of Inhaled Drug Products - Explainer Animation
Pharmaceutical powder compound delivery testing.
Taking a breath with Copley's Inhaler testing apparatus
Tasks: 3D Modelling, Animation, Shading & Rendering
Tools: Maya, V-Ray and After Effects
Client: Copley Scientific
Year: 2021
Agency/Studio: Direct
The animation "System for Improved In Vitro-In Vivo Correlations (IVIVCs) of Inhaled Drug Products" explains how, through the use of the Mixing Inlet and a breath simulator, a realistic patient breath profile can be generated through the inhaler, whilst a constant flow rate can be maintained through the cascade impactor. The smooth merging of the two flow regimes is achieved using the Mixing Inlet, ensuring that the aerosol cloud generated by the inhaler, under patient realistic conditions, is not modified as it passes into the cascade impactor at a constant flow rate for subsequent size fractionation and analysis.
Such a system provides an alternative to the traditional USP and Ph. Eur. based systems, which were primarily conceived for quality control (QC) purposes, allowing the acquisition of more patient relevant data, in-vitro, during research and development (R&D).
This has particular value when undertaking bioequivalence testing for generic products. The animation also features the adult version of the Alberta Idealised Throat (AIT), which is an improved representation of the human throat geometry, based on considerable academic research. This replaces the simplified, right-angled induction port used in traditional test methods.
